New synthesis method of chlorpropamid

The chlorpropamid (1) is an antidiabetic drug synthetized from chlorobenzene (2) in five steps through intermediates p-clorobenzenesulfonyl chloride (3), calcium p-chlorobenzene sulfonyl cyanamide (6), p-clorobenzenesulfonyl cyanamide (7), p-clorobenzenesulfonyl urea (8) and then the compound 8 was condensated with n-propylamine. The product have melting point, Rf, IR spectral data that suitable with to the chlopropamid extracted from Novopropamid tablet of Canada.

: Synthesis of some derivatives of 1, 3, 4-thiodiazol for preparing the diuretic drug acetazolamide

The acetazolamide was prepared from hydrazine sulfate and ammonium or potasium thiocy anate via the hydrazodicarbothiamide and 2,2-diamino-1,3,4-thiadiazole-5, 5-disulfide (DTD). From DTD by acetylation, chlorosulfoxidation sulfonamidation, acetazolamide was obtained. The effects of the molecular of reagents, solvent, and catalysts and the reaction time were studied in order to find the best condition for synthesis of these compounds. We found acetone as a catalytic agent for preparation of hydrazodicacbo thiamide. The result showed that the yield increased by one and a half time more than that without acetone. We also exposed the explanation for the catalytic role of acetone on increasing the yield of hydrazodicarbothiamide preparation.

Combination of thin layer chromatography and computer for quantitative analysis of preparation in some mixtures resulting from the etherification of dihydroartemisinine

A new method for quantitative dethermination of some derivatives of artemisinin was studied. The method was TLC coupled with personal computer. The relative deviation was 2-3%.

Study on some derivatives of the secodin alkaloid

Some unstable secodines 14, 16, 4, 5, stable hydrosecodines 13, 15 ,19, 20, 21, 22, 23 and aspidospermane type compounds 17,18, 9, 10, were prepared. Chemical properties of these compounds were studied by the transformation of stable secodine 13 into unstable secodines 4 and 5, result: vincadifformine 9 and 10 were generated.

Study on some heterocyclic compounds used as drug for synthesis of sulphamethazine

Study on some heterocyclic compounds used as drug for synthesis of sulphamethazine

Study on some sulfonamides utilized as drugs

From P-acctamino benzen sulfochlorua to P-acoltamino benzen sulfonamide to p- acctamido benzen sulfonylure to N1- n butyl, N2- sulfanilyure. This product is identical with carbutamide which pureed from Bucarban tablet (Hungary) in both infrared and melting point

Synthesis of carbutamine, an antidiabetic drug

Purpose: find out synthesis of carbutamine. Experiment: from acetanilid through 5 steps: (1) Preparing acetamidobenzen sulfoclorua; (2) Preparing p-acetamindobenzensulfonamid; (3) Preparing p-acetamidobenzen sulfonylure; (4) Preparing N1-nbutyl, N2-su;lanilylure. (5) Product completely resemble carbutamid, which extracted refinement from bucarban tablet of Hungary, as infra-red spectrum and sensitivity.